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TNK2 preserves epidermal growth factor receptor expression on the cell surface and enhances migration and invasion of human breast cancer cells.
Howlin J, Rosenkvist J, Andersson T. Howlin J, et al. Breast Cancer Res. 2008;10(2):R36. doi: 10.1186/bcr2087. Epub 2008 Apr 24. Breast Cancer Res. 2008. PMID: 18435854 Free PMC article.
TNK2 was suggested to regulate Cdc42-driven migration by activation of breast cancer antioestrogen resistance 1 (BCAR1); however, distinct from this effect is evidence for a role of TNK2 in the regulation of epidermal growth factor receptor (EGFR) endocytosis …
TNK2 was suggested to regulate Cdc42-driven migration by activation of breast cancer antioestrogen resistance 1 (BCAR1); howev …
ACK1/TNK2 tyrosine kinase: molecular signaling and evolving role in cancers.
Mahajan K, Mahajan NP. Mahajan K, et al. Oncogene. 2015 Aug 6;34(32):4162-7. doi: 10.1038/onc.2014.350. Epub 2014 Oct 27. Oncogene. 2015. PMID: 25347744 Free PMC article. Review.
The emergence of a non-receptor tyrosine kinase (non-RTK), ACK1 (also known as activated Cdc42-associated kinase 1 or TNK2) as an oncogenic kinase, has uncovered novel mechanisms by which tyrosine kinase signaling promotes cancer progression. ...ACK1 interacts with the est …
The emergence of a non-receptor tyrosine kinase (non-RTK), ACK1 (also known as activated Cdc42-associated kinase 1 or TNK2) as an onc …
The non-receptor tyrosine kinase TNK2/ACK1 is a novel therapeutic target in triple negative breast cancer.
Wu X, Zahari MS, Renuse S, Kelkar DS, Barbhuiya MA, Rojas PL, Stearns V, Gabrielson E, Malla P, Sukumar S, Mahajan NP, Pandey A. Wu X, et al. Oncotarget. 2017 Jan 10;8(2):2971-2983. doi: 10.18632/oncotarget.13579. Oncotarget. 2017. PMID: 27902967 Free PMC article.
In our previous phosphoproteomic profiling effort, we identified the non-receptor tyrosine kinase TNK2 as activated in a majority of aggressive TNBC cell lines. In the current study, we show that high expression of TNK2 in breast cancer cell lines correlates …
In our previous phosphoproteomic profiling effort, we identified the non-receptor tyrosine kinase TNK2 as activated in a majority of …
ACK1 is dispensable for development, skin tumor formation, and breast cancer cell proliferation.
Brandao R, Kwa MQ, Yarden Y, Brakebusch C. Brandao R, et al. FEBS Open Bio. 2021 Jun;11(6):1579-1592. doi: 10.1002/2211-5463.13149. Epub 2021 May 2. FEBS Open Bio. 2021. PMID: 33730447 Free PMC article.
DMBA/TPA-induced skin tumor formation did not reveal significant differences between ACK1 ko and control mice. Deletion of the ACK1 gene in the breast cancer cell lines MDA-MB-231, 67NR, MCF7, 4T1, and T47D caused no differences in growth. Furthermore, EGF-induced phosphor …
DMBA/TPA-induced skin tumor formation did not reveal significant differences between ACK1 ko and control mice. Deletion of the ACK1 gene in …
Research Progress of the Functional Role of ACK1 in Breast Cancer.
Liu X, Wang X, Li L, Han B. Liu X, et al. Biomed Res Int. 2019 Oct 20;2019:1018034. doi: 10.1155/2019/1018034. eCollection 2019. Biomed Res Int. 2019. PMID: 31772931 Free PMC article. Review.
In this review, we will be summarizing the structural characteristics, activation, and regulation of ACK1 in breast cancer, aiming to deeply understand the functional and mechanistic role of ACK1 and provide novel therapeutic strategies for breast cancer treatment.. …
In this review, we will be summarizing the structural characteristics, activation, and regulation of ACK1 in breast cancer, aiming to …
Epigenetic reprogramming of cell cycle genes by ACK1 promotes breast cancer resistance to CDK4/6 inhibitor.
Sawant M, Wilson A, Sridaran D, Mahajan K, O'Conor CJ, Hagemann IS, Luo J, Weimholt C, Li T, Roa JC, Pandey A, Wu X, Mahajan NP. Sawant M, et al. Oncogene. 2023 Jul;42(29):2263-2277. doi: 10.1038/s41388-023-02747-x. Epub 2023 Jun 17. Oncogene. 2023. PMID: 37330596 Free PMC article.
Hormone receptor-positive, HER2-negative advanced breast cancers exhibit high sensitivity to CDK4/6 inhibitors such as palbociclib. ...Immunohistochemical studies of tissue microarray revealed increased activation of non-receptor tyrosine kinase, ACK1 (also known as TNK …
Hormone receptor-positive, HER2-negative advanced breast cancers exhibit high sensitivity to CDK4/6 inhibitors such as palbociclib. . …
(R)-9bMS Inhibited the Protein Synthesis and Autophagy of Triple Negative Breast Cancer Cells via Regulating miR-4660/mTOR Axis.
Bai X, Han G, Li F, Li W, Bu P, Zhang H, Xie J. Bai X, et al. Protein Pept Lett. 2023;30(4):295-303. doi: 10.2174/0929866530666230302150750. Protein Pept Lett. 2023. PMID: 36861798
BACKGROUND: Unlike other subtypes of breast cancer, triple negative breast cancer (TNBC) exhibits aggressive and metastatic behaviors and a lack of effective targeted therapeutics. (R)-9bMS, a small-molecule inhibitor of the non-receptor tyrosine kinase 2 (TNK2 …
BACKGROUND: Unlike other subtypes of breast cancer, triple negative breast cancer (TNBC) exhibits aggressive and metastatic be …
Amplification of ACK1 promotes gastric tumorigenesis via ECD-dependent p53 ubiquitination degradation.
Xu SH, Huang JZ, Chen M, Zeng M, Zou FY, Chen D, Yan GR. Xu SH, et al. Oncotarget. 2017 Feb 21;8(8):12705-12716. doi: 10.18632/oncotarget.6194. Oncotarget. 2017. PMID: 26498357 Free PMC article.
Amplification or over-expression of an activated Cdc42-associated kinase 1 (ACK1) gene is common in breast, lung and ovarian cancers. However, little is known about the role of ACK1 in gastric tumorigenesis. ...
Amplification or over-expression of an activated Cdc42-associated kinase 1 (ACK1) gene is common in breast, lung and ovarian cancers. …
Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation.
Mahajan K, Coppola D, Challa S, Fang B, Chen YA, Zhu W, Lopez AS, Koomen J, Engelman RW, Rivera C, Muraoka-Cook RS, Cheng JQ, Schönbrunn E, Sebti SM, Earp HS, Mahajan NP. Mahajan K, et al. PLoS One. 2010 Mar 19;5(3):e9646. doi: 10.1371/journal.pone.0009646. PLoS One. 2010. PMID: 20333297 Free PMC article.
We have uncovered that growth factors binding to RTKs lead to activation of a non-receptor tyrosine kinase, Ack1 (also known as ACK or TNK2), which directly phosphorylates AKT at an evolutionarily conserved tyrosine 176 in the kinase domain. ...Further, expression levels o …
We have uncovered that growth factors binding to RTKs lead to activation of a non-receptor tyrosine kinase, Ack1 (also known as ACK or TN …
The rho-specific guanine nucleotide exchange factor Dbs regulates breast cancer cell migration.
Liu Z, Adams HC 3rd, Whitehead IP. Liu Z, et al. J Biol Chem. 2009 Jun 5;284(23):15771-80. doi: 10.1074/jbc.M901853200. Epub 2009 Apr 14. J Biol Chem. 2009. PMID: 19366686 Free PMC article.
Here we report that Dbs regulates cell motility in tumor-derived, human breast epithelial cells through activation of Cdc42 and Rac1. Cdc42 and Rac1 are activated in T47D cells that stably express onco- or proto-Dbs, and activation is dependent upon growth of the cells on …
Here we report that Dbs regulates cell motility in tumor-derived, human breast epithelial cells through activation of Cdc42 and Rac1. …
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